IGRT for Treatment of Laryngeal Chondrosarcoma

Ahnaf Syed Noakhali

Abstract

Laryngeal chondrosarcoma is a rare type of sarcoma reportedly comprising a segment of laryngeal tumors. As a result, the incidence and survival of patients with this tumor has been hard to observe. Our goal was to analyze this data based on various categories under investigation. Several cases were identified, representing 0.2% of all laryngeal tumors. Median age at diagnosis was 57.4 years. Men and women constituted 72% and 28% of patients, respectively. Tumors were locally invasive with 39% T4 disease and infrequent regional and distant metastases. The 1-year, 5-year, and 10-year disease-specific survival for LC was 96.5%, 88.6%, and 84.8%, respectively, compared to 88.3%, 68.2%, and 59.3%, respectively for patients with all other laryngeal tumors (P values<0.01). Relative survival was 94.9% at 1 year, 88.5% at 5 years, and 88.4% at 10 years. This analysis represents the largest LC study sample to date, allowing for evaluation of incidence and long-term survival. Chondrosarcoma occurs infrequently, is locally invasive, but only rarely metastasizes. The treatment with tomtherapy is significantly better than for such malignancies.

Keywords

Chondrosarcoma, tomtherapy, radiotherapy, metastasis

References

[1] Lancaster, Madeline A., Magdalena Renner, Carol-Anne Martin, Daniel Wenzel, Louise S. Bicknell, Matthew E. Hurles, Tessa Homfray, Josef M. Penninger, Andrew P. Jackson, and Juergen A. Knoblich. "Cerebral organoids model human brain development and microcephaly." Nature 501, no. 7467 (2013): 373.

[2] Acheva, Anna, Giuseppe Schettino, and Kevin M. Prise. "Pro-inflammatory Signaling in a 3D Organotypic Skin Model after Low LET Irradiation—NF-κB, COX-2 Activation, and Impact on Cell Differentiation." Frontiers in immunology 8 (2017): 82.

[3] Yadav, Poonam, Bhudatt R. Paliwal, and Kevin Kozak. "Dosimetric comparison of photon and proton treatment techniques for chondrosarcoma of thoracic spine." Medical Dosimetry 38, no. 3 (2013): 233-237.

[4] Britten, Richard A., Vahagn Nazaryan, Leslie K. Davis, Susan B. Klein, Dmitri Nichiporov, Marc S. Mendonca, Mark Wolanski, Xiliang Nie, Jerry George, and Cynthia Keppel. "Variations in the RBE for cell killing along the depth-dose profile of a modulated proton therapy beam." Radiation research 179, no. 1 (2012): 21-28.

[5] Carabe, Alejandro, Maryam Moteabbed, Nicolas Depauw, Jan Schuemann, and Harald Paganetti. "Range uncertainty in proton therapy due to variable biological effectiveness." Physics in Medicine & Biology 57, no. 5 (2012): 1159.

[6] Chaudhary, Pankaj, Thomas I. Marshall, Francesca M. Perozziello, Lorenzo Manti, Frederick J. Currell, Fiona Hanton, Stephen J. McMahon et al. "Relative biological effectiveness variation along monoenergetic and modulated Bragg peaks of a 62-MeV therapeutic proton beam: a preclinical assessment." International Journal of Radiation Oncology* Biology* Physics90, no. 1 (2014): 27-35.

[7] Cuaron, John J., Chang Chang, Michael Lovelock, Daniel S. Higginson, Dennis Mah, Oren Cahlon, and Simon Powell. "Exponential increase in relative biological effectiveness along distal edge of a proton Bragg peak as measured by deoxyribonucleic acid double-strand breaks." International Journal of Radiation Oncology* Biology* Physics 95, no. 1 (2016): 62-69.

[8] Giantsoudi, Drosoula, Roshan V. Sethi, Beow Y. Yeap, Bree R. Eaton, David H. Ebb, Paul A. Caruso, Otto Rapalino et al. "Incidence of CNS injury for a cohort of 111 patients treated with proton therapy for medulloblastoma: LET and RBE associations for areas of injury." International Journal of Radiation Oncology* Biology* Physics 95, no. 1 (2016): 287-296.

[9] Jin, Ming-Zhu, Run-Run Han, Guan-Zhong Qiu, Xiang-Chun Ju, Ge Lou, and Wei-Lin Jin. "Organoids: An intermediate modeling platform in precision oncology." Cancer letters 414 (2018): 174-180.

[10] Kralik, S. F., C. Y. Ho, W. Finke, J. C. Buchsbaum, C. P. Haskins, and C-S. Shih. "Radiation necrosis in pediatric patients with brain tumors treated with proton radiotherapy." American Journal of Neuroradiology (2015)

Cites this article as

A. S. N. "IGRT for Treatment of Laryngeal Chondrosarcoma", International Journal of Innovative Research in Engineering & Management (IJIREM), Vol-6, Issue-2, Page No-9-12, 2019. Available from: